Table 1.
Demographic, clinical, anthropometric and metabolic data of NT1 children and adolescents relative to their engagement in leisure-time physical/sporting activities.
| NT1-LTPAs (n = 30) | NT1-No LTPAs (n = 20) | t(48) | p | ||
|---|---|---|---|---|---|
| Mean ± SD | Mean ± SD | ||||
| DEMOGRAPHIC AND CLINICAL DATA | |||||
| Male/female | 17/13 | 11/9 | 0.01† | ns | |
| Age at NT1 onset, y | 9.21 ± 2.93 | 8.94 ± 3.83 | 0.28 | ns | |
| Age at observation, y | 12.16 ± 2.70 | 13.23 ± 3.23 | −1.27 | ns | |
| Diagnostic delay, y | 2.74 ± 2.77 | 4.01 ± 2.89 | −1.56 | ns | |
| ESS-CHAD | 13.40 ± 3.02 | 16.10 ± 3.40 | −2.94 | 0.005 | |
| Cataplexy frequency, (%) | ≥1/day | 60 | 65 | 291.5†† | ns |
| < 1/day and ≥1/week | 23.3 | 15 | |||
| < 1/week and ≥1/month | 3.3 | 5 | |||
| < 1/month and ≥1/in 3 months | 10.0 | 10 | |||
| < 1/in 3 months and ≥1/in 6 months | 3.3 | 5 | |||
| Chronotype (m\i\e) | 8\20\2 | 1\15\4 | 5.03† | ns | |
| NEUROPHYSIOLOGICAL AND BIOCHEMICAL DATA | |||||
| MSLT-sol, min | 3.95 ± 3.50 | 3.21 ± 2.71 | 0.80 | ns | |
| SOREMP, n° | 4.57 ± 0.63 | 4.55 ± 0.83 | 286†† | ns | |
| CSF hcrt-1, pg/mL | 27.71 ± 27.20 (n = 26/30) | 21.09 ± 37.57 (n = 20/20) | 0.69 | ns | |
| HLA DQB1*0602 positivity | 30/30 | 20/20 | |||
| ANTHROPOMETRIC AND METABOLIC FEATURES | |||||
| BMI | 22.87 ± 3.88 | 27.94 ± 8.41 | −2.88 | 0.006 | |
| BMI category (underweight\normal\over\obese) | 0/16/9/5 | 1/1/12/6 | 13.29† | < 0.005 | |
| Glucose, mg/dL | 82.93 ± 7.07 | 80.67 ± 6.36 | 1.12 | ns | |
| Total cholesterol, mg/dL | 172.40 ± 29.90 | 168.40 ± 40.80 | 0.40 | ns | |
| HDL-C, mg/dL | 56.03 ± 13.15 | 48.35 ± 11.03 | 2.16 | < 0.05 | |
| LDL-C, mg/dL | 101.30 ± 26.40 | 101.40 ± 29.67 | −0.01 | ns | |
| Triglycerides, mg/dL | 88.60 ± 44.41 | 93.45 ± 43.31 | −0.38 | ns | |
NT1-LTPAs, Narcolepsy type 1 subjects regularly engaged in leisure-time physical/sporting activities; NT1-No LTPAs, Narcolepsy type 1 subjects not engaged in leisure-time physical/sporting activities; ESS-CHAD, Epworth sleepiness scale for children and adolescent; Chronotype (m, morning type; i, intermediate type; e, evening type); MSLT-sol, mean sleep latency at MSLT; SOREMPs, sleep-onset REM periods at MSLT; CSF hcrt-1, cerebrospinal fluid hypocretin-1; BMI, body mass index; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol. Unless otherwise specified, the t-test was used for group comparisons.
Chi-squared test,
Mann-Whitney U test.