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. 2018 Aug 24;9:1901. doi: 10.3389/fimmu.2018.01901

Figure 3.

Figure 3

Memory peripheral Tfh (pTfh) cells in HIV+ children express high programmed cell death protein 1 (PD-1) levels that correlate with disease progression. (A) Comparison between PD-1 expression memory pTfh cells of HIV−, ART−, and ART+ children. (B) Correlation between the frequency of total memory pTfh cells and their PD-1 expression. (C) Linear regression plot of PD-1 expression on memory pTfh cells vs. age at ART initiation in ART+ subjects. (D) Correlations between the frequency of PD-1+ memory pTfh cells and HIV log copies/mL, %CD4+ T cells, and CD4:CD8 ratios in HIV+ children (ART− in orange and ART+ in blue). Correlations between PD-1 expression on memory pTfh and (E) CD38+ HLA-DR+ CD4 and CD8 T cells and (F) plasma sCD163 levels. Significant p values are shown for statistical analysis of HIV+ (black), ART− (orange), and ART+ (blue) groups (****p < 0.0001, ***p < 0.001, **p < 0.01, and *p < 0.05).