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. 2018 Aug 24;9:1901. doi: 10.3389/fimmu.2018.01901

Figure 4.

Figure 4

Differentiated B cell populations correlate with low memory peripheral Tfh (pTfh) cells expressing high programmed cell death protein 1 (PD-1) levels. Comparisons of (A) total B cell and (B) IgD+ B cell levels in HIV−, ART−, and ART+ children. (C) FACS plot showing representative gating to identify B cell differentiation subsets by CD21 and CD27. Plot shown is gated on CD19+ lymphocytes. Comparisons between (D) CD27−CD21+ naïve (BN), (E) CD27+ CD21+ resting memory (BRM), (F) CD27+ CD21− activated memory (BAM), and (G) CD27−CD21− tissue-like memory (BTLM) B cell subsets in HIV−, ART−, and ART+ and their correlations with total and PD-1+ memory pTfh cell frequencies in ART− (orange) and ART+ (blue) children. Significant p values are shown for statistical analysis of HIV+ (black), ART− (orange), and ART+ (blue) groups (****p < 0.0001, ***p < 0.001, **p < 0.01, and *p < 0.05).