Table 3.
Comparison of retinal thickness measurements between HbSS and HbSC genotypes with measurements averaged from both eyes (unless only 1 eye eligible for inclusion)
| Mean (SD) Retinal Thickness (microns) |
p Values for Difference |
||||
|---|---|---|---|---|---|
| ETDRS subfield | HbSC (n = 91) | HbSS (n = 93) | Uncorrected | Adjusted for Age and Sex | With Multiple Testing Correction |
| Central | 206 (23) | 203 (20) | 0.258 | 0.154 | NA |
| Inner superior | 288 (22) | 284 (28) | 0.255 | 0.045* | 0.052 |
| Inner nasal | 289 (19) | 287 (23) | 0.570 | 0.193 | NA |
| Inner inferior | 286 (22) | 282 (24) | 0.305 | 0.086 | NA |
| Inner temporal | 272 (22) | 266 (32) | 0.088 | 0.024* | 0.031* |
| Outer superior | 262 (17) | 258 (20) | 0.145 | 0.027* | 0.033* |
| Outer nasal | 274 (19) | 271 (20) | 0.297 | 0.070 | NA |
| Outer inferior | 255 (20) | 250 (17) | 0.089 | 0.023* | 0.029* |
| Outer temporal | 240 (21) | 230 (24) | 0.005* | 0.002* | 0.004* |
ETDRS, Early Treatment Diabetic Retinopathy Study; NA, not applicable.
p values are from unpaired t test. The correction for multiple testing was only applied to parameters with significant p values (after adjusting for age and sex).
*
p < 0.05 was taken as significant.