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. 2018 Jul 18;596(17):4237–4251. doi: 10.1113/JP276300

Figure 5. Neuronal sprouting in TNX‐KO mucosa.

Figure 5

Representative immunohistochemical images taken from sections of WT mouse colonic mucosa (A, C) and myenteric plexus (B, D). CGRP‐IR is shown in green (A) where there was a threefold proliferation of CGRP‐IR nerve endings in the colonic mucosa of TNX‐KO mice (P < 0.0001) (E). This was also observed with PGP9.5 in red (C), although this increase was smaller for PGP‐IR endings (P = 0.0224) (E). No changes were seen in either marker in the myenteric plexus (P = 0.3950, P = 0.1368) (F). Data are shown as individual values with standard deviation. Statistical analysis was performed using an unpaired Student's t test (P < 0.05). Scale bar in all panels = 20 μm.