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. 2018 Jul 18;596(17):4237–4251. doi: 10.1113/JP276300

Figure 6. Increased colonic afferent sensitivity in TNX‐KO distal colon.

Figure 6

Nerve activity from colonic afferent units innervating the distal colon in WT vs. TNX‐KO. Nerve activity displayed by spike frequency (Hz) and raw trace (mV) in WT vs. TNX‐KO (A). Baseline splanchnic nerve activity is significantly increased in TNX‐ KO (B) (P = 0.0069) as well as average peak firing rate during distension (C) (P = 0.0384) without changes in colonic compliance (D) (n = 3 WT vs. n = 3 KO). Data are shown as individual values with standard deviation. Statistical analysis was performed using an unpaired Student's t test (P < 0.05).