Figure 4. α2δ‐1 mediates increased presynaptic NMDAR activity of RVLM–projecting PVN neurons in SHRs.
A–D, original traces and cumulative probability plots show the effect of bath application of 50 μmol L−1 AP5 on the frequency and amplitude of mEPSCs of labelled PVN neurons pretreated with vehicle or 100 μmol L−1 gabapentin in slices from WKY rats and SHRs. E and F, summary data show the effects of gabapentin and AP5 on the frequency (E) and amplitude (F) of mEPSCs in labelled PVN neurons from WKY rats (vehicle, n = 10 neurons; gabapentin, n = 12 neurons) and SHRs (n = 11 neurons in each group). ** P < 0.01 compared to baseline in the WKY + vehicle group. # P < 0.05 compared to baseline in the SHR + vehicle group.