Figure 7. Schematic representation shows the proposed role of α2δ‐1 in the regulation of synaptic NMDARs of PVN presympathetic neurons and sympathetic outflow in SHRs.

In normotensive condition, most NMDARs are not associated with α2δ‐1 in the PVN. In hypertensive condition, α2δ‐1 is upregulated and physically interacts with NMDARs to promote synaptic trafficking of α2δ‐1–bound NMDARs, which leads to increased pre‐ and postsynaptic NMDAR activity of RVLM‐projecting PVN neurons. The increased synaptic NMDAR activity in the PVN contributes to elevated sympathetic vasomotor activity in SHRs. [Color figure can be viewed at http://wileyonlinelibrary.com]