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. 2018 Jul 4;596(17):3967–3976. doi: 10.1113/JP275887

Table 2.

Central haemodynamic and arterial variables at baseline and during infusion of sodium nitroprusside (SNP)

Baseline (n = 19) SNP low rate (n = 19) SNP high rate (n = 16) P value
Mean arterial pressure (mmHg) 83 ± 8 69 ± 8* 58 ± 4* † < 0.0001
Heart rate (min–1) 55 ± 9 82 ± 14* 94 ± 16* † < 0.0001
Stroke volume (ml) 96 ± 9 93 ± 16 91 ± 18 0.1538
Cardiac output (l min–1) 5.3 ± 1.0 7.4 ± 1.5* 8.4 ± 2.0* † < 0.0001
TPR (mmHg min l–1) 17 ± 4 10 ± 2* 7 ± 1* † < 0.0001
Thoracic admittance index (S × 104) 102 ± 22 98 ± 20* 97 ± 20* 0.0042
Arterial CO2 tension (mmHg) 41 ± 3 39 ± 3* 37 ± 4* † < 0.0001
Arterial O2 tension (mmHg) 106 ± 8 117 ± 14* 126 ± 12* † < 0.0001
Arterial O2 saturation (%) 98 (98–98) 99 (98–99)* 99 (99–99)* † 0.0003
Haemoglobin concentration (mM) 8.8 ± 0.7 8.9 ± 0.7* 8.9 ± 0.7* 0.0002
Arterial O2 content (mM) 8.6 ± 0.7 8.8 ± 0.7* 8.8 ± 0.7* < 0.0001
Arterial glucose (mM) 5.3 ± 0.2 5.6 ± 0.4* 6.1 ± 0.5* † < 0.0001
Arterial lactate (mM) 0.5 (0.4–0.6) 0.7 (0.6–0.8)* 0.6 (0.5–0.7)* † 0.0001

TPR, total peripheral resistance. Values are means ± SD or median (IQR). P values represent the overall effect as estimated by a repeated measure mixed model. * P < 0.05 vs. baseline. P < 0.05 for low vs. high SNP infusion rate.