Table 2.
Baseline (n = 19) | SNP low rate (n = 19) | SNP high rate (n = 16) | P value | |
---|---|---|---|---|
Mean arterial pressure (mmHg) | 83 ± 8 | 69 ± 8* | 58 ± 4* † | < 0.0001 |
Heart rate (min–1) | 55 ± 9 | 82 ± 14* | 94 ± 16* † | < 0.0001 |
Stroke volume (ml) | 96 ± 9 | 93 ± 16 | 91 ± 18 | 0.1538 |
Cardiac output (l min–1) | 5.3 ± 1.0 | 7.4 ± 1.5* | 8.4 ± 2.0* † | < 0.0001 |
TPR (mmHg min l–1) | 17 ± 4 | 10 ± 2* | 7 ± 1* † | < 0.0001 |
Thoracic admittance index (S × 104) | 102 ± 22 | 98 ± 20* | 97 ± 20* | 0.0042 |
Arterial CO2 tension (mmHg) | 41 ± 3 | 39 ± 3* | 37 ± 4* † | < 0.0001 |
Arterial O2 tension (mmHg) | 106 ± 8 | 117 ± 14* | 126 ± 12* † | < 0.0001 |
Arterial O2 saturation (%) | 98 (98–98) | 99 (98–99)* | 99 (99–99)* † | 0.0003 |
Haemoglobin concentration (mM) | 8.8 ± 0.7 | 8.9 ± 0.7* | 8.9 ± 0.7* | 0.0002 |
Arterial O2 content (mM) | 8.6 ± 0.7 | 8.8 ± 0.7* | 8.8 ± 0.7* | < 0.0001 |
Arterial glucose (mM) | 5.3 ± 0.2 | 5.6 ± 0.4* | 6.1 ± 0.5* † | < 0.0001 |
Arterial lactate (mM) | 0.5 (0.4–0.6) | 0.7 (0.6–0.8)* | 0.6 (0.5–0.7)* † | 0.0001 |
TPR, total peripheral resistance. Values are means ± SD or median (IQR). P values represent the overall effect as estimated by a repeated measure mixed model. * P < 0.05 vs. baseline. † P < 0.05 for low vs. high SNP infusion rate.