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. 2018 Jul 28;11(8):1306. doi: 10.3390/ma11081306

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Distribution of adherent cell orientation (in percentage) on blanket tantalum film and comb structures with trench widths between 0.21 μm and 100 μm. The cell orientation is characterized as the angle (φ) between the nuclei long axis and the patterned trench axes. The number of adherent cells characterized (n) in each area is also presented in the plots. Each bin represents the percentage of cell population in a ±10° interval deviated from the trench axis. Results show that cells aligned preferentially with the trench axes.