Table 4.

The fatty acids existing in fish oils for preventing or treating cutaneous wounds.

Composition	Experimental Model	Wound-Induced Approach	Benefit	Reference
Fish oil	Pig	Full-thickness skin excision	Fast wound closure at day 2	Shingel et al. [99]
Fish oil	Rat	Full-thickness skin excision	Accelerated healing process and increased IL-10	Peng et al. [101]
DHA	Rat	Full-thickness skin excision	Accelerated healing process and increased GPR120 and TGF-β	Arantes et al. [102]
14R,21-dihydroxy-DHA and 14S,21-dihydroxy-DHA	Mouse	Full-thickness skin excision	Increased granulation tissue region (>65%) and reduced epithelial gap	Lu et al. [103]
DHA and EPA	Human	Blisters in the forearms	Increased IL-1β expression in the wound sites	McDaniel et al. [104]
ALA, LA, and oleic acid	Mouse	Full-thickness skin excision	Faster wound closure by oleic acid than ALA and LA	Cardoso et al. [105]
LA and oleic acid	Rat	Full-thickness skin excision	Reduced necrotic cell layer thickness	Pereira et al. [106]
LA	Rat	Streptozotocin- induced diabetic wound	Increased leukocyte accumulation and angiogenesis	Rodrigues et al. [107]
Conjugated LA	Human	Fractional laser ablation	Reduced edema and itching	Wu and Goldman [108]

ALA, α-linolenic acid; GPR120, G-protein-coupled receptor 120; LA, linoleic acid; TGF-β, transforming growth factor β.