Table 4.
Inhibitory effects of compounds 1–7 on superoxide anion generation and elastase release in fMLF/CB-induced human neutrophils.
| Compounds | Superoxide Anion | Elastase Release | |
|---|---|---|---|
| IC50 (μM) a | Inh b % | Inh b % | |
| 1 | >30 | 32.1 ± 4.3 ** | 37.6 ± 5.0 ** |
| 2 | >30 | 4.0 ± 6.7 | 23.5 ± 6.6 * |
| 3 | >30 | 44.5 ± 4.6 *** | 35.6 ± 6.2 ** |
| 4 | >30 | 6.4 ± 4.2 | 27.6 ± 6.4 ** |
| 5 | >30 | 2.6 ± 6.2 | 30.5 ± 4.6 ** |
| 6 | 26.2 ± 1.0 | 64.6 ± 0.8 *** | 42.4 ± 5.1 ** |
| 7 | >30 | 3.5 ± 5.3 | 20.7 ± 4.1 ** |
| Idelalisib | 0.07 ± 0.01 | 102.8 ± 2.2 *** | 99.6 ± 4.2 |
a Concentration necessary for 50% inhibition (IC50). b Percentage of inhibition (Inh %) at 30 μM. Data are presented as mean ± S.E.M. (n = 3–4); * p < 0.05, ** p < 0.01, *** p < 0.001 compared with the control value.