Figure 4. Effect of paramylon film dressing on inflammatory cytokines in mouse serum. Serum cytokines were measured by ELISA. A: IFN-γ levelwas increased on day 3 in mice with paramylon film dressing, that was decreased on day 5, but sustained on day 5 in mice with cellulose filmdressing (two-way ANOVA, Tukey–Kramer post-hoc test, *p<0.05) B: Change of IL-6 on days 3 and 5 after wounding in each group (two-wayANOVA, Tukey–Kramer post-hoc test, n.s.). C: VEGF level was increased at days 3 and 5 in mice with cellulose film dressing (two-way ANOVA,Tukey–Kramer post-hoc test, †p<0.05 cellulose vs. control and paramylon). Bars are expressed as mean±SE (control: n=6 and 5; paramylon: n=6and 6; cellulose: n=7 and 7 on days 3 and 5 .