Table I. Cytotoxicity of paclitaxel against differentiated PC12, nonmalignant and malignant oral cells. Differentiated rat PC12 cells (day 5) inoculated at different density (3125-25000 cells/cm2), human normal epithelial (HGEP) and mesenchymal cells [human gingival fibroblast (HGF), human periodontal ligament fibroblast (HPLF), human pulp cell (HPC)], and human oral squamous cell carcinoma cell lines derived from gingiva (Ca9-22) and tongue (HSC-2, HSC-3, HSC-4) were treated for 24 or 48 h with 0.005-50 μM paclitaxel, and the relative viable cell number was determined by MTT method and the 50% cytotoxic concentration (CC50) was determined. Each value represents mean from six determinations .

TS: Tumor specificity.