Table I. Anticancer drug sensitivity of PC12 cells during nerve growth factor (NGF)-induced differentiation. PC12 cells were induced to neuronal differentiation by treatment for 3 or 5 days with 50 ng/ml NGF in serum-free Dulbecco’s modified Eagle’s medium, and then treated for further 48 h with different concentrations of anticancer drugs in six determinations. The 50% cytotoxic concentration (CC50) was determined from the dose–response curve. The experiments (Exp) were performed three times to check reproducibility.

DXR, Doxorubicin; 5-FU, 5-fluorouracil; MTX, methotrexate; SD, standard deviation.