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. 2018 Aug 6;11(1):13–21. doi: 10.2478/intox-2018-0002

Figure 5.

Figure 5

PIX induces lysosomal and mitochondrial disruption in differentiated H9c2 cells. NR uptake (A) and MTT reduction (B) assays in differentiated H9c2 cells exposed to 0.1, 1 or 10 μM PIX for 48 h. Values are expressed as percentage of control and are shown as mean ± standard deviation. The results were obtained from 4 independent experiments using 20 wells. The statistical analyses were made using the Kruskal-Wallis test, followed by Dunn’s post-hoc test (A) and the ANOVA test, followed by the Tukey post hoc test (B) (*p<0.05 and ****p<0.0001 versus control; ####p<0.0001 versus PIX 0.1 μM; +p<0.05, ++++p<0.0001 versus PIX 1 μM).