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S1943 NMHC-IIA phosphorylation enhances matrix degradation. MDA-MB-231 cells expressing wild-type or S1943E NMHC-IIA were plated on Oregon Green 488- gelatin for 7 h and then evaluated for matrix degradation. (A) Percentage of cells that degrade the gelatin, and (B) the average degradation area per cell (pixels/cell). Data represent the mean ± SEM from 3 independent experiments, > 50 cells per condition per experiment. Statistical analyses were performed using a Student’s t-test.
