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. Author manuscript; available in PMC: 2018 Nov 1.

Published in final edited form as: Toxicol Sci. 2017 Nov 1;160(1):15–29. doi: 10.1093/toxsci/kfx153

Figure 4. — A. Significance of correlations between the A4 high dose group (left) and reference datasets for male vs. female mice, female mice treated with testosterone, and the STAT5b biomarker. Fifty genes from the 60 that were altered in the high dose group were also significantly altered in at least one of the comparisons. The male vs. female comparisons were from wild-type adult mice on standard diets. The GEO number associated with each study is indicated. Female mice were treated with testosterone (0.9 mg) or sesame oil (vehicle) twice a week for three weeks. Gene expression in the liver was analyzed either directly after treatment (GSE13388–1) or after three weeks of hormone withdrawal (GSE13388–2). The STAT5b biomarker was described previously (Oshida et al., 2016a,b). All of the indicated comparisons were compared to the A4 bioset using the Running Fisher’s test. The –Log(p-value)s of the comparisons are shown. B. Significance of the correlations between the genes altered by EE and PRED and the STAT5b biomarker. The –Log(p-value)s with negative values represent pairwise comparisons with negative correlation.

Figure 4. — A. Significance of correlations between the A4 high dose group (left) and reference datasets for male vs. female mice, female mice treated with testosterone, and the STAT5b biomarker. Fifty genes from the 60 that were altered in the high dose group were also significantly altered in at least one of the comparisons. The male vs. female comparisons were from wild-type adult mice on standard diets. The GEO number associated with each study is indicated. Female mice were treated with testosterone (0.9 mg) or sesame oil (vehicle) twice a week for three weeks. Gene expression in the liver was analyzed either directly after treatment (GSE13388–1) or after three weeks of hormone withdrawal (GSE13388–2). The STAT5b biomarker was described previously (Oshida et al., 2016a,b). All of the indicated comparisons were compared to the A4 bioset using the Running Fisher’s test. The –Log(p-value)s of the comparisons are shown. B. Significance of the correlations between the genes altered by EE and PRED and the STAT5b biomarker. The –Log(p-value)s with negative values represent pairwise comparisons with negative correlation.