Table 1.
% case survival from cancer of the vulva by period post-diagnosis; South Australian major public hospitals, 1984–2016 diagnosesa
| Number of cases | Surv 1 yr | Surv 2 yr | Surv 5 yr | Surv 10 yr | Surv 20 yr | p value** | Hazard ratiob (95% CLs) -adjusted |
|---|---|---|---|---|---|---|---|
| All (n = 383) | 84.1 | 75.7 | 70.0 | 61.5 | 55.3 | ||
| Age at diagnosis (yrs.): | |||||||
| < 50 (n = 56) | 96.4 | 91.1 | 91.1 | 82.8 | 75.6 | p < 0.001 | 1.00 |
| 50–69 (n = 100) | 86.6 | 83.5 | 77.4 | 65.6 | 57.6 | 2.10 (1.06, 4.17) | |
| 70–79 (n = 113) | 82.0 | 66.6 | 59.1 | 51.9 | 45.0 | 3.14 (1.65, 6.00) | |
| 80+ (n = 114) | 77.8 | 70.5 | 63.6 | 56.1 | 52.6 | 2.25 (1.16, 4.40) | |
| FIGO stage: | |||||||
| I (n = 167) | 94.5 | 92.0 | 85.8 | 77.7 | 70.1 | p < 0.001 | 1.00 |
| II (n = 103) | 92.2 | 81.5 | 71.6 | 61.4 | 55.5 | 1.62 (1.04, 2.53) | |
| III (n = 68) | 68.3 | 43.5 | 41.8 | 34.1 | 28.9 | 3.89 (2.47, 6.13) | |
| IV (n = 29) | 27.6 | 27.6 | 27.6 | 27.6 | – | 7.29 (3.94, 13.49) | |
| (Unknown (n = 16)) | (93.8) | (93.8) | (93.8) | (76.7) | (68.2) | (1.06 (0.37, 3.09)) | |
| Differentiation: | |||||||
| Well (n = 102) | 93.1 | 86.1 | 79.9 | 69.9 | 60.3 | p < 0.001 | 1.00 |
| Moderate (n = 136) | 84.1 | 74.8 | 70.1 | 62.5 | 56.2 | 0.80 (0.51, 1.25) | |
| Poorly/undifferentiated (n = 75) | 69.1 | 54.0 | 46.9 | 41.9 | 40.1 | 1.71 (1.06, 2.76) | |
| (Unknown (n = 70) | (86.8) | (85.3) | (79.8) | (66.8) | (63.6) | (0.94 (0.51, 1.71)) | |
| Histology: | |||||||
| Squamous cell carcinoma (n = 341) | 85.1 | 76.0 | 69.8 | 61.1 | 55.1 | p = 0.955 | 1.00 |
| Other (n = 42) | 75.9 | 73.4 | 70.9 | 64.1 | 57.4 | 0.69 (0.40, 1.21) | |
| Socioeconomic (SEIFA): | |||||||
| Low (n = 138) | 84.5 | 76.8 | 74.3 | 66.7 | 59.2 | p = 0.684 | 1.00 |
| Low/med (n = 75) | 87.7 | 80.8 | 73.7 | 55.5 | 55.5 | 1.25 (0.78, 2.02) | |
| Med/high (n = 77) | 88.1 | 77.4 | 68.7 | 58.7 | 53.2 | 1.19 (0.76, 1.88) | |
| High (n = 93) | 77.4 | 68.7 | 61.8 | 61.8 | 52.0 | 1.14 (0.73, 1.76) | |
| Geographic remoteness: | |||||||
| Low (n = 314) | 83.5 | 75.0 | 69.1 | 60.8 | 55.0 | p = 0.534 | 1.00 |
| Moderate (n = 45) | 86.0 | 76.5 | 76.5 | 70.4 | 62.8 | 1.00 (0.56, 1.79) | |
| High (n = 24) | 87.5 | 83.3 | 70.1 | 56.1 | 48.1 | 1.40 (0.76, 2.59) | |
| Diagnostic period (calendar years.): | |||||||
| 1984–99 (n = 199) | 83.9 | 76.4 | 71.9 | 63.3 | 56.7 | p = 0.498 | 1.00 |
| 2000–16 (n = 184) | 84.6 | 74.9 | 67.6 | 59.3 | – | 0.88 (0.61, 1.27) | |
**Derived from unadjusted Cox proportional hazards regression
aKaplan-Meier product-limit disease-specific estimates; date of censoring of live cases - Dec 31, 2016
bDerived from Cox proportional hazards regression, adjusting for other variables in the Table