Table 3.
% cancers of the vulva having radiotherapy (and odds ratios for radiotherapy) as part of the primary course of treatment; Australian major public hospitals, 1984–2016 diagnoses
| Number of cases | Radiotherapy (%) |
p value* Mann-Whitney or Pearson Chi-square |
Odds ratiosa - adjusted (95% CIs) |
|---|---|---|---|
| All (n = 383) | 26.4 | – | – |
| Age at diagnosis (yrs.): | |||
| < 50 (n = 56) | 30.4 | MW p = 0.098 | 1.00 |
| 50–69 (n = 100) | 25.0 | 0.41 (0.16, 1.06) | |
| 70–79 (n = 113) | 35.4 | 0.70 (0.28, 1.75) | |
| 80+ (n = 114) | 16.7 | 0.18 (0.06, 0.48) | |
| FIGO stage: | |||
| I (n = 167) | 7.2 | MW p < 0.001 (excluding UK) | 1.00 |
| II (n = 103) | 24.3 | 5.97 (2.60, 13.72) | |
| III (n = 68) | 66.2 | 32.11 (13.24, 77.85) | |
| IV (n = 29) | 58.6 | 25.37 (8.54, 75.37) | |
| (Unknown (n = 16)) | (12.5) | (1.81 (0.33, 10.05)) | |
| Differentiation: | |||
| Well (n = 102) | 11.8 | MW p = 0.001 (excluding UK) | 1.00 |
| Moderate (n = 136) | 28.7 | 1.87 (0.81, 4.33) | |
| Poorly/undifferentiated (n = 75) | 42.7 | 2.67 (1.06, 6.68) | |
| (Unknown) (n = 70) | (25.7) | (2.18 (0.80, 5.98)) | |
| Histology: | |||
| Squamous cell carcinoma (n = 341) | 26.4 | p = 0.978 | 1.00 |
| Other (n = 42) | 26.2 | 0.87 (0.32, 2.36) | |
| Socioeconomic (SEIFA): | |||
| Low (n = 138) | 26.8 | MW p = 0.565 | 1.00 |
| Low/med (n = 75) | 17.3 | 0.63 (0.25, 1.56) | |
| Med/high (n = 77) | 32.5 | 1.60 (0.74, 3.45) | |
| High (n = 93) | 28.0 | 0.77 (0.36, 1.64) | |
| Geographic remoteness: | |||
| Low (n = 314) | 25.5 | MW p = 0.380 | 1.00 |
| Moderate (n = 45) | 28.9 | 2.29 (0.53, 3.13) | |
| High (n = 24) | 33.3 | 1.38 (0.44, 4.36) | |
| Diagnostic period (calendar years.): | |||
| 1984–99 (n = 199) | 21.1 | p = 0.015 | 1.00 |
| 2000–16 (n = 184) | 32.1 | 1.72 (0.93, 3.15) | |
*Derived from Mann-Whitney (ordinal) or Pearson chi-square (1d.f.) (binary)
aDerived from multiple logistic regression, adjusting for other variables in the Table