Table 4.
% cancers of the vulva having chemotherapy (and odds ratios for chemotherapy) as part of the primary course of treatment; Australian major public hospitals, 1984–2016 diagnoses
| Number of cases | Systemic therapy (%) |
p value* Mann-Whitney or Fisher Exact Test |
Odds ratiosa adjusted (95% CIs) |
|---|---|---|---|
| All (n = 383) | 6.0 | – | – |
| Age at diagnosis (yrs.): | |||
| < 50 (n = 56) | 14.3 | MW p < 0.001 | 1.00 |
| 50–69 (n = 100) | 8.0 | 0.36 (0.08, 1.56) | |
| 70–79 (n = 113) | 6.2 | 0.21 (0.05, 0.95) | |
| 80+ (n = 114) | 0.0 | 0.00 (0.00, 0.30) | |
| FIGO stage: | |||
| I (n = 167) | 3.0 | MW p = 0.002 (excluding UK) | 1.00 |
| II (n = 103) | 1.9 | 1.46 (0.22, 2.53) | |
| III (n = 68) | 17.6 | 18.77 (3.83, 92.02) | |
| IV (n = 29) | 13.8 | 9.98 (1.58, 63.24) | |
| (Unknown (n = 16)) | (0.0) | (0.00 (0.00, 5.78)) | |
| Differentiation: | |||
| Well (n = 102) | 3.9 | MW p = 0.080 (excluding UK) | 1.00 |
| Moderate (n = 136) | 5.1 | 0.47 (0.09, 2.53) | |
| Poorly/undifferentiated (n = 75) | 10.7 | 1.21 (0.22, 6.60) | |
| (Unknown) (n = 70) | (5.7) | (0.67 (0.12, 3.75)) | |
| Histology: | |||
| Squamous cell carcinoma (n = 341) | 6.5 | FET p = 0.492 | 1.00 |
| Other (n = 42) | 2.4 | 0.31 (0.03, 3.48) | |
| Socioeconomic (SEIFA): | |||
| Low (n = 138) | 8.7 | MW p = 0.795 | 1.00 |
| Low/med (n = 75) | 0.0 | 0.00 (0.00, 0.75) | |
| Med/high (n = 77) | 3.9 | 0.74 (0.12, 4.71) | |
| High (n = 93) | 8.6 | 4.97 (1.00, 24.87) | |
| Geographic remoteness: | |||
| Low (n = 314) | 5.4 | MW p = 0.223 | 1.00 |
| Moderate (n = 45) | 4.4 | 0.26 (0.02, 2.87) | |
| High (n = 24) | 16.7 | 10.72 (1.32, 87.37) | |
| Diagnostic period (calendar years.): | |||
| 1984–99 (n = 199) | 1.5 | FET p < 0.001 | 1.00 |
| 2000–16 (n = 184) | 10.9 | 8.54 (2.14, 34.02) | |
*Derived from Mann-Whitney U Test (ordinal) or Fisher Exact Test (binary)
aDerived from multiple logistic regression, adjusting for other variables in the Table