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. 2018 Aug 31;18:133. doi: 10.1186/s12883-018-1139-8

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — The three-gene signature correlated with decreases in DFS and OS in glioma. (a) The comparison of alteration frequency in NOTCH1 between glioma and embryonal tumor. (b) The alteration frequency of NOTCH1 in detailed cancer types. (c) The indicated types of genomic alterations for the three genes in the TCGA data set (GBM, n = 577) within the cBioPortal database are shown; only the proportion of cohorts containing the three-gene signature are included. Each column is for individual tumor. (d) Analysis of DFS using the TCGA cohort (GBM) (P < 0.05). (e) The indicated types of genomic alterations for the three genes in a merged cohort (TCGA, Cell 2016, n = 1084) of Brain Lower Grade Glioma (LGG) and GBM within the cBioPortal database are shown; only the proportion of cohorts containing the three-gene signature are included. Each column is for individual tumor. (f) Analysis of OS using the TCGA cohort (merged LGG and GBM) (P < 0.001). (g) Analysis of DFS using the TCGA cohort (n = 513, LGG) (p = 0.588)