Table 1.

Phase 1 study treatment design (latin square) (Condition 1 = asymptomatic; Condition 2 = symptomatic; Condition 3 = symptomatic-treated)

	Period 1	Period 2	Period 3
Group A	Condition 1	Condition 2	Condition 3
Group B	Condition 2	Condition 3	Condition 1
Group C	Condition 3	Condition 1	Condition 2