Supplementary Table 1.

Cox proportional hazards regression assessing the association of obesity with systemic progression and overall survival

	Systemic progression	p	Overall survival	p
	Multivariable HR (95% CI)		Multivariable HR (95% CI)
Obesity	0.79 (0.46–1.34)	0.38	1.06 (0.60–1.86)	0.84
Age			1.09 (1.04–1.14)	<0.001
Pathological Gleason grade (ref=7)
6	-	-	1.42 (0.66–3.07)	0.37
8–10	2.50 (1.43–4.38)	0.001	1.46 (0.72–2.94)	0.28
pT stage (ref = pT2)
pT3/4	2.99 (1.60–5.58)	<0.001	1.50 (0.75–3.01)	0.26
pN1 disease (ref = N0-x)	2.06 (0.82–5.14)	0.12	2.47 (1.09–5.60)	0.03
Preoperative PSA*	0.95 (0.73–1.23)	0.70
Positive margins	1.39 (0.80–2.42)	0.24
Adjuvant ADT	0.60 (0.26–1.38)	0.23

Variables included in multivariable model included the variable of interest (obesity) and variables significant at the p <0.05 level in univariable analysis.

^*PSA modeled as log₂PSA.

ADT: androgen-deprivation therapy; CI: confidence interval; HR: hazard ratio; PSA: prostate-specific antigen.