Fig. 1.

Precision diagnosis and management of neurodegenerative disease relies on integration of population-level data and individual data derived from multiple sources. Effective utilization will require informatics applications to aggregate and filter data, which can drive development of clinical decision support tools for deployment in clinical settings. Developing tools to systematically capture clinical outcomes at the point of service delivery will facilitate refinement of the clinical decision support tools, creating a learning healthcare system and closing the loop in evidence-based care.