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. Author manuscript; available in PMC: 2018 Aug 31.
Published in final edited form as: Nature. 2018 Mar 5;556(7699):126–129. doi: 10.1038/nature26156

Extended Data Figure 7. Intermediates of nucleolar pre-60S assembly.

Extended Data Figure 7

The structural data presented in this paper (states 1, 2, and 3) are complemented by recent data on pre-60S assembly: states C (EMD-3893) and E (EMD-3891)16. State 1 is highly similar to state A (EMD-3888)16. States 2 and 2A correspond closely to state B (EMD-3889)16, but state B lacks the Ssf1–Rrp15–Rrp14 module and Mak11. Built assembly factors that become ordered or leave in subsequent particles are indicated with arrows. Two possible pathways are shown that result in the final incorporation of the DEAD-box helicase Spb4 (previously unidentified16).