Table 2.
Significant allele (top) and haplotype (bottom) associations in patients with LGI1 (n = 68) or CASPR2 (n = 31) antibodies
| Antibody group | Allele / haplotype | OR | 95% CI lower | 95% CI upper | Fisher’s exact test | Corrected (Hochberg) P-value |
|---|---|---|---|---|---|---|
| LGI1 | B*57:01 | 3.7 | 2.0 | 6.5 | 5.2 × 10−5 | 1.0 × 10−2 |
| LGI1 | C*06:02 | 3.9 | 2.4 | 6.3 | 1.6 × 10−7 | 4.6 × 10−5 |
| LGI1 | DPB1*11:01 | 4.9 | 2.6 | 8.7 | 8.4 × 10−6 | 2.0 × 10−3 |
| LGI1 | DQA1*02:01 | 8.9 | 5.2 | 16.1 | 3.0 × 10−17 | 8.7 × 10−15 |
| LGI1 | DQB1*02:02 | 8.1 | 4.9 | 13.7 | 9.5 × 10−17 | 2.8 × 10−14 |
| LGI1 | DQB1*03:03 | 4.7 | 2.8 | 7.7 | 3.6 × 10−8 | 1.0 × 10−5 |
| LGI1 | DRB1*07:01 | 27.6 | 12.9 | 72.2 | 1.4 × 10−28 | 4.1 × 10−26 |
| CASPR2 | DRB1*11:01 | 9.4 | 4.6 | 19.3 | 2.0 × 10−8 | 5.7 × 10−6 |
| LGI1 | DRB1*07:01-DQA1*02:01-DQB1*02:02 | 5.2 | 3.2 | 8.6 | 4.7 × 10−11 | 2.3 × 10−9 |
| LGI1 | DRB1*07:01-DQA1*02:01-DQB1*03:03 | 3.1 | 1.7 | 5.5 | 4.4 × 10−4 | 2.1 × 10−2 |
| LGI1 | DPA1*02:01-DPB1*11:01 | 4.8 | 2.5 | 8.5 | 1.0 × 10−5 | 3.8 × 10−4 |
| LGI1 | C*06:02-B*57:01 | 3.6 | 1.9 | 6.2 | 1.3 × 10−4 | 8.8 × 10−3 |
| CASPR2 | DRB1*11:01-DQA1*05:01-DQB1*03:01 | 7.4 | 3.5 | 15.2 | 1.1 × 10−6 | 5.7 × 10−5 |
Corrected P-values indicate comparison between disease and healthy controls.