Figure 2.

Injection of young rats with Dex and/or propofol did not affect their body weights in adult age.

Notes: Young rats were injected with propofol or Dex either alone or in combination with another drug, and the body weights of different groups of rats were monitored longitudinally. Data are expressed as the mean±SEM of each group at different time points (n=25 per group). P group: i.p. injected with 50 mg/kg propofol, and 40–60 min later, when the righting reflex was recovered, the procedure was repeated one more time; PD₂₅, PD₅₀ and PD₇₅ groups: intraperitoneal injection with 25, 50 and 75 μg/kg Dex, and 30 min later, intervention with propofol; LPD group: intracerebroventricular injection with 25 μg/5 μL LY294002, and 30 min later, intervention with Dex and propofol; TPD group: intraperitoneal injection with 1 mg/kg TDZD-8, and 30 min later, intervention with Dex and propofol. DS₁ and DS₂ groups: intracerebroventricular or intraperitoneal injection with DMSO; F group: intraperitoneal injection with intralipid; L group: intracerebroventricular injection with LY294002; T group: intraperitoneal injection with TDZD-8; Dex group: intraperitoneal injection with Dex.

Abbreviations: Dex, dexmedetomidine; DMSO, dimethyl sulfoxide; SEM, standard error of the mean.