Figure 6.

Western blot analysis of the relative levels of PSD₉₅ expression in the hippocampus of rats.

Notes: P group: i.p. injected with 50 mg/kg propofol, and 40–60 min later, when the righting reflex was recovered, the procedure was repeated one more time; PD₂₅, PD₅₀ and PD₇₅ groups: intraperitoneal injection with 25, 50 and 75 μg/kg Dex, and 30 min later, intervention with propofol; LPD group: intracerebroventricular injection with 25 μg/5 μL LY294002, and 30 min later, intervention with Dex and propofol; TPD group: intraperitoneal injection with 1 mg/kg TDZD-8, and 30 min later, intervention with Dex and propofol. DS₁ and DS₂ groups: intracerebroventricular or intraperitoneal injection with DMSO; F group: intraperitoneal injection with intralipid; L group: intracerebroventricular injection with LY294002; T group: intraperitoneal injection with TDZD-8; Dex group: intraperitoneal injection with Dex. (A) The relative levels of PSD₉₅ expression in the hippocampus of individual rats were determined by Western blot assay. (B) Data are representative images or are expressed as the mean±SEM of each group (n=5 per group) from three separate experiments. ^*p<0.05 versus NS group; ^#p<0.05 versus P group; ^p<0.05 versus PD₇₅ group; double symbols mean p<0.01.

Abbreviations: DMSO, dimethyl sulfoxide; sSEM, standard error of the mean.