Table 4.

Prevalence of Pfdhfr and Pfdhps haplotypes

Study sites	Years	Pfdhfr						Pfdhps						Pfdhfr+Pfdhps
		N	ICNI (%)	IRNI (%)	NCNI (%)	NCSI (%)	p-value	N	AAKAA (%)	AGKAA (%)	SGKAA (%)	SAKAA (%)	p-value	N	Quadruple (%)	p-value
Franceville	2011	15	0.0	100.0	0.0	0.0	0.6	4	0.0	0.0	100.0	0.0	0.48	3	100.0	0.32
	2012	23	0.0	95.7	4.3	0.0		0	0.0	0.0	0.0	0.0		0	0.0
	2013	22	0.0	100.0	0.0	0.0		12	0.0	8.3	83.3	8.3		12	100.0
	2014	19	5.3	89.4	0.0	0.0		10	10.0	30.0	50.0	10.0		9	88.9
Koulamoutou	2013	23	0.0	100.0	0.0	0.0	1	19	15.8	0.0	68.4	15.8	0.33	15	73.3	0.32
	2014	26	0.0	100.0	0.0	0.0		22	8.3	8.3	83.3	0.0		12	91.7
Lastourville	2013	29	0.0	96.6	0.0	3.4	1	22	4.6	0.0	86.4	9.1	0.24	24	83.3	0.32
	2014	17	0.0	94.1	0.0	5.9		7	14.3	14.3	71.4	0.0		7	100.0
All sites	2013	74	0.0	98.6	0.0	1.4	0.54	53	6.9	1.7	72.4	19	0.05	51	80.4	1
	2014	62	1.6	95.2	0.0	1.6		29	9.7	16.1	64.5	9.7		28	92.9

Note: Quadruple mutations = Pfdhfr (51+59+108) and Pfdhps (437).