Table S5.

Baseline characteristics of hip fracture patients (n=68,487) according to preoperative selective serotonin reuptake inhibitor (SSRI) use 2006–2016 after imputation of BMI

Variables	All patients		SSRI
			Non-users		Former users		Current users
	n	%	n	%	n	%	n	%
Total	68,487	100	52,438	76.6	2,777	4.0	13,272	19.4
Median age (years)	83		83		83		84
Age (years)
65–74	13,271	19.4	10,571	20.2	533	19.2	2,167	16.3
75–84	26,086	38.1	19,768	37.7	1,159	41.7	5,159	38.9
≥85	29,130	42.5	22,099	42.1	1,085	39.1	5,946	44.8
Gender
Male	19,750	28.8	15,541	29.6	730	26.3	3,479	26.2
Female	48,737	71.2	36,897	70.4	2,047	73.7	9,793	73.8
Marital status
Married	20,300	29.6	16,105	30.7	842	30.3	3.353	25.3
Unmarried	48,187	70.4	36,333	69.3	1,935	69.7	9,919	74.7
Housing
Own accommodation	31,075	45.4	25,537	48.7	1,126	40.5	4,412	33.2
Homeless	22	<0.1	20	0.1	0	0.0	2	<0.1
Residential institution	7,105	10.4	4,213	8.0	408	14.7	2,484	18.7
Unknown	30,285	44.2	22,668	43.2	1,243	44.8	6,374	48.0
Fracture type
Fracture of femoral neck	36,341	53.1	27,854	53.1	1,451	52.3	7,036	53.0
Per- and subtrochanteric fracture	32,146	46.9	24,584	46.9	1,326	47.7	6,236	46.9
Operation type
Alloplastic surgery	46,859	68.4	35,843	68.4	1,902	68.5	9,114	68.7
Osteosynthesis	21,628	31.6	16,595	31.6	875	31.5	4,158	31.3
Operation delay (hours)
<24	41,671	60.8	31,859	60.8	1,721	62.0	8,091	61.0
24–48	12,517	18.3	9,646	18.4	461	16.6	2,410	18.1
>48	14,299	20.9	10,933	20.8	595	21.4	2,771	20.9
Operation year
2006–2010	32,131	46.9	23,822	45.4	1,342	48.3	6,967	52.5
2011–2016	36,356	53.1	28,616	54.6	1,435	51.7	6,305	47.5
BMI (kg/m2)a
<18.5: underweight	7,672	11.2	5,806	11.1	357	12.9	1,509	11.4
≥18.5 <25: normal weight	35,397	51.7	27,163	51.8	1,440	51.8	6,794	51.2
≥25: overweight or obese	25,418	37.1	19,469	37.1	980	35.3	4,969	37.4
Charlson Comorbidity Index
Low (0)	27,283	39.8	22,505	42.9	840	30.3	3,938	29.7
Medium (1–2)	27,787	40.6	20,365	38.8	1,244	44.8	6,178	46.5
High (3+)	13,417	19.6	9,568	18.3	693	24.9	3,156	23.8
Comorbidity
Myocardial infarction	3,762	5.5	2,820	5.4	151	5.4	791	6.0
Congestive heart failure	6,289	9.2	4,632	8.8	291	10.5	1,366	10.3
Peripheral vascular disease	5,511	8.1	4,060	7.7	267	9.6	1,184	8.9
Cerebrovascular disease	12,678	18.5	8,467	16.2	689	24.8	3,522	26.5
Dementia	6,733	9.8	3,859	7.4	433	15.6	2,441	19.4
Chronic pulmonary disease	8,663	12.7	6,191	11.8	496	17.9	1,976	14.9
Connective tissue disease	3,243	4.7	2,480	4.7	139	5.0	624	4.7
Ulcer disease	3,855	5.6	2,673	5.1	224	8.1	958	7.2
Liver disease	870	1.3	646	1.2	46	1.7	178	1.3
Diabetes type 1 and 2	6,689	9.8	5,005	9.5	281	10.1	1,403	10.6
Hemiplegia	175	0.3	111	0.2	12	0.4	52	0.4
Moderate to severe renal disease	2,688	3.9	1,973	3.4	132	4.8	583	4.4
Cancer	10,957	16.0	8,351	15.9	501	18.0	2,105	15.9
Other medication
NSAIDs	7,681	11.2	5,869	11.2	334	12.0	1,478	11.1
Corticosteroids	4,158	6.1	3,068	5.9	186	6.7	904	6.8
Anticoagulants	26,716	39.0	19,323	36.9	1,064	38.3	6,329	47.7
Statins	13,052	19.1	9,581	18.3	505	19.2	2,966	22.4
Other antidepressants	7,975	11.6	4,977	9.5	596	21.5	2,402	18.1
Antipsychotics	4,992	7.3	2,899	5.5	319	11.5	1,774	13.4

Note:

^aBMI values from m =1 data.

Abbreviation: NSAIDs, non-steroidal anti-inflammatory drugs.