Table S7.
Baseline characteristics of hip fracture patients (n=68,487) according to preoperative selective serotonin reuptake inhibitor (SSRI) use 2006–2016 after changing the exposure definition
| Variables | All patients
|
SSRIs
|
||||||
|---|---|---|---|---|---|---|---|---|
| Non-users
|
Former users
|
Current users
|
||||||
| n | % | n | % | n | % | n | % | |
| Total | 68,487 | 100 | 52,841 | 77.2 | 1,116 | 1.6 | 14,530 | 21.2 |
| Median age (years) | 83 | 83 | 82 | 84 | ||||
| Age (years) | ||||||||
| 65–74 | 13,271 | 19.4 | 10,620 | 20.1 | 230 | 20.6 | 2,421 | 16.6 |
| 75–84 | 26,086 | 38.1 | 19,910 | 37.7 | 487 | 43.6 | 5,689 | 39.2 |
| ≥85 | 29,130 | 42.5 | 22,311 | 42.2 | 399 | 35.8 | 6,420 | 44.2 |
| Gender | ||||||||
| Male | 19,750 | 28.8 | 15,690 | 29.7 | 274 | 24.5 | 3,786 | 26.1 |
| Female | 48,737 | 71.2 | 37,151 | 70.3 | 842 | 75.5 | 10,744 | 73.9 |
| Marital status | ||||||||
| Married | 20,300 | 29.6 | 16,247 | 30.7 | 320 | 28.7 | 3,733 | 25.7 |
| Unmarried | 48,187 | 70.4 | 36,594 | 69.3 | 796 | 71.3 | 10,797 | 74.3 |
| Housing | ||||||||
| Own accommodation | 31,075 | 45.4 | 25,728 | 48.7 | 414 | 37.1 | 4,933 | 33.9 |
| Homeless | 22 | <0.1 | 17 | <0.1 | 3 | 0.3 | 2 | <0.1 |
| Residential institution | 7,150 | 10.4 | 4,232 | 8.0 | 190 | 17.0 | 2,683 | 18.5 |
| Unknown | 30,285 | 44.2 | 22,864 | 43.3 | 509 | 45.6 | 6,912 | 47.6 |
| Fracture type | ||||||||
| Fracture of femoral neck | 36,341 | 53.1 | 28.073 | 53.1 | 595 | 53.3 | 7.673 | 52.8 |
| Per- and subtrochanteric fracture | 32,146 | 46.9 | 24,768 | 46.9 | 521 | 46.7 | 6,857 | 47.2 |
| Operation type | ||||||||
| Alloplastic surgery | 46,859 | 68.4 | 36,122 | 68.4 | 761 | 68.2 | 9,976 | 68.7 |
| Osteosynthesis | 21,628 | 31.6 | 16,719 | 31.6 | 355 | 31.8 | 4,554 | 31.3 |
| Operation delay (hours) | ||||||||
| <24 | 41,671 | 60.8 | 32,090 | 60.7 | 700 | 62.7 | 8,881 | 61.1 |
| 24–48 | 12,517 | 18.3 | 9,715 | 18.4 | 196 | 17.6 | 2,606 | 17.9 |
| >48 | 14,299 | 20.9 | 11,036 | 20.9 | 220 | 19.7 | 3,043 | 21.0 |
| Operation year | ||||||||
| 2006–2010 | 32,131 | 46.9 | 24,061 | 45.5 | 539 | 48.3 | 7,531 | 51.8 |
| 2011–2016 | 36,356 | 53.1 | 28,780 | 54.5 | 577 | 51.7 | 6,999 | 48.2 |
| BMI (kg/m2) | ||||||||
| <18.5: underweight | 5,988 | 8.8 | 4,623 | 8.7 | 104 | 9.3 | 1,261 | 8.7 |
| ≥18.5 <25: normal weight | 31,582 | 46.1 | 24,630 | 46.6 | 492 | 44.1 | 6,460 | 44.5 |
| ≥25: overweight or obese | 17,622 | 25.7 | 13,616 | 25.8 | 292 | 26.2 | 3,714 | 25.5 |
| Unknown | 13,295 | 19.4 | 9,972 | 18.9 | 228 | 20.4 | 3,095 | 21.3 |
| Charlson Comorbidity Index | ||||||||
| Low (0) | 27,283 | 39.8 | 22,655 | 42.9 | 339 | 30.4 | 4,289 | 29.5 |
| Medium (1–2) | 27,787 | 40.6 | 20,544 | 38.9 | 494 | 44.3 | 6,749 | 46.5 |
| High (3+) | 13,417 | 19.6 | 9,642 | 18.2 | 283 | 25.3 | 3,492 | 24.0 |
| Comorbidity | ||||||||
| Myocardial infarction | 3,762 | 5.5 | 2,848 | 5.4 | 57 | 5.1 | 857 | 5.9 |
| Congestive heart failure | 6,289 | 9.2 | 4,677 | 8.9 | 125 | 11.2 | 1,487 | 10.2 |
| Peripheral vascular disease | 5,511 | 8.1 | 4,092 | 7.7 | 112 | 10.0 | 1,307 | 9.0 |
| Cerebrovascular disease | 12,678 | 18.5 | 8,549 | 16.2 | 278 | 24.9 | 3,851 | 26.5 |
| Dementia | 6,733 | 9.8 | 3,891 | 7.4 | 172 | 15.4 | 2,670 | 18.4 |
| Chronic pulmonary disease | 8,663 | 12.7 | 6,229 | 11.8 | 187 | 16.8 | 2,247 | 15.5 |
| Connective tissue disease | 3,243 | 4.7 | 2,495 | 4.7 | 60 | 5.4 | 688 | 4.7 |
| Ulcer disease | 3,855 | 5.6 | 2,693 | 5.1 | 81 | 7.3 | 1,081 | 7.4 |
| Liver disease | 870 | 1.3 | 647 | 1.2 | 24 | 2.2 | 199 | 1.4 |
| Diabetes type 1 and 2 | 6,689 | 9.8 | 5,041 | 9.5 | 131 | 11.7 | 1,517 | 10.4 |
| Hemiplegia | 175 | 0.3 | 112 | 0.2 | 3 | 0.3 | 60 | 0.4 |
| Moderate to severe renal disease | 2,688 | 3.9 | 1,995 | 3.8 | 54 | 4.8 | 639 | 4.4 |
| Cancer | 10,957 | 16.0 | 8,440 | 16.0 | 175 | 15.7 | 2,342 | 16.1 |
| Other medication | ||||||||
| NSAIDs | 7,681 | 11.2 | 5,926 | 11.2 | 128 | 11.5 | 1,627 | 11.2 |
| Corticosteroids | 4,158 | 6.1 | 3,100 | 5.9 | 86 | 7.7 | 972 | 6.7 |
| Anticoagulants | 26,716 | 39.0 | 19,520 | 36.9 | 425 | 38.1 | 6,771 | 46.6 |
| Statins | 13,052 | 19.1 | 9,698 | 18.4 | 182 | 16.3 | 3,172 | 21.8 |
| Other antidepressants | 7,975 | 11.6 | 4,905 | 9.3 | 372 | 33.3 | 2,698 | 18.6 |
| Antipsychotics | 4,992 | 7.3 | 2,897 | 5.5 | 165 | 14.8 | 1,930 | 13.3 |
Abbreviation: NSAIDs, non-steroidal anti-inflammatory drugs.