Table 3.

Univariate and multivariate analyses of prognostic factors in 1,296 patients with GC

Factors	Univariate analysis		Multivariate analysis
	HR (95% CI)	P-value*	HR (95% CI)	P-value*
Age (years)		<0.001		<0.001
<60	1.00		1.00
≥60	1.490 (1.252, 1.774)		1.467 (1.228, 1.752)
Sex		0.667
Female	1.00
Male	1.042 (0.864, 1.256)
Tumor size (cm)		<0.001		0.988
<5	1.00		1.00
≥5	1.718 (1.443, 2.046)		0.999 (0.833, 1.198)
Tumor location		<0.001		<0.001
Upper third	1.00		1.00
Middle third	0.673 (0.535, 0.847)	0.001	0.800 (0.632, 1.012)	0.062
Lower third	0.456 (0.373, 0.558)	<0.001	0.602 (0.489, 0.742)	<0.001
Histological grade		0.027		0.032
Well differentiated	1.00		1.00
Poorly differentiated	1.328 (1.032, 1.710)		1.327 (1.024, 1.720)
NLR		<0.001
<5.0	1.00
≥5.0	2.313 (1.707, 3.134)
Fibrinogen (mg/dL)		<0.001
≤400	1.00
>400	1.618 (1.330, 1.969)
PLR		0.069
<150	1.00
≥150 and ≤300	1.210 (1.007, 1.454)	0.042
>300	1.325 (0.910, 1.930)	0.142
MPV (fL)		0.571
<10	1.00
≥10	0.940 (0.757, 1.166)
F-NLR		<0.001		<0.001
0	1.00		1.00
1	1.619 (1.331, 1.969)	<0.001	1.274 (1.043, 1.555)	0.008
2	3.326 (2.139, 5.172)	<0.001	2.228 (1.423, 3.487)	<0.001
TNM stage		<0.001		<0.001
I	1.00		1.00
II	3.006 (1.764, 5.122)	<0.001	2.525 (1.475, 4.321)	0.008
III	11.059 (6.807, 17.967)	<0.001	9.129 (5.565, 14.977)	<0.001
Adjuvant chemotherapy		0.373
No	1.00
Yes	0.922 (0.771, 1.102)

Notes: F-NLR, combination of fibrinogen and the NLR.

^*Values in bold refer to P-value with significance (P<0.05).

Abbreviations: GC, gastric cancer; MPV, mean platelet volume; NLR, neutrophil–lymphocyte ratio; PLR, platelet–lymphocyte ratio; TNM, tumor–node–metastasis.