Figure 1.

Domain structure of CCN4/WISP-1 and splice variants.

Notes: The following are the highly conserved domains in CCN proteins: SP, IGFBP, VWC, TSP1, and CT. WISP-1v is a splice variant that lacks exon 3, which contains the VWC domain. WISP-1vx contains a truncated IGFBP domain, creating a frameshift that results in loss of the VWC and TSP1 domains.

Abbreviations: SP, signaling peptide; IGFBP, insulin-like growth factor binding protein; VWC, von Willebrand factor type C; TSP1, thrombospondin 1; CT, C-terminal.