Table 5.

Stratified analyses between IGF2BP2 rs1470579 A>C polymorphism and NSCLC risk by sex, age, BMI, smoking status, and alcohol consumption

Variable	IGF2BP2 rs1470579 A>C (case/control)a			Adjusted ORb (95% CI); P
	AA	AC	CC	AA	AC	CC	AC/CC	CC vs (AC/AA)
Sex
Male	165/344	101/198	21/45	1.00	1.05 (0.76–1.45); 0.789	1.00 (0.55–1.81); 0.999	1.04 (0.76–1.41); 0.824	0.98 (0.55–1.76); 0.953
Female	137/249	86/152	11/41	1.00	1.01 (0.72–1.43); 0.935	0.46 (0.23–0.94); 0.032	0.90 (0.65–1.24); 0.506	0.46 (0.23–0.92); 0.028
Age
<60	148/273	82/159	8/43	1.00	0.94 (0.66–1.33); 0.725	0.36 (0.16–0.80); 0.012	0.82 (0.59–1.14); 0.237	0.37 (0.17–0.81); 0.013
≥60	154/320	105/191	24/43	1.00	1.12 (0.82–1.54); 0.479	1.08 (0.62–1.89); 0.787	1.11 (0.83–1.51); 0.481	1.03 (0.60–1.78); 0.909
Smoking status
Never	185/471	113/284	19/72	1.00	1.00 (0.76–1.33); 0.978	0.64 (0.37–1.11); 0.111	0.93 (0.71–1.21); 0.585	0.64 (0.38–1.09); 0.102
Ever	117/122	74/66	13/14	1.00	1.12 (0.73–1.70); 0.610	0.89 (0.40–1.99); 0.771	1.08 (0.72–1.61); 0.720	0.85 (0.39–1.87); 0.688
Alcohol consumption
Never	259/548	161/318	24/82	1.00	1.09 (0.85–1.40); 0.510	0.61 (0.37–0.99); 0.046	0.99 (0.78–1.25); 0.908	0.59 (0.36–0.95); 0.031
Ever	43/45	26/32	8/4	1.00	0.76 (0.38–1.51); 0.427	2.23 (0.58–8.50); 0.242	0.90 (0.47–1.72); 0.740	2.51 (0.68–9.25); 0.168
BMI (kg/m2)
<24	189/303	125/191	23/52	1.00	1.03 (0.76–1.39); 0.842	0.69 (0.40–1.19); 0.183	0.96 (0.72–1.27); 0.760	0.68 (0.40–1.16); 0.158
≥24	113/290	62/159	9/34	1.00	1.04 (0.72–1.52); 0.823	0.78 (0.35–1.70); 0.526	1.00 (0.70–1.43); 0.996	0.76 (0.35–1.65); 0.494

Notes:

^aFor IGF2BP2 rs1470579 A>C, the genotyping was successful in 521 (100.00%) NSCLC cases and 1,029 (99.90%) controls.

^bAdjusted for multiple comparisons (age, sex, BMI, smoking status, and alcohol consumption [besides stratified factors accordingly]) in a logistic regression model. Bold values are statistically significant (P<0.05).

Abbreviations: NSCLC, non-small-cell lung cancer; BMI, body mass index.