Table 7.

Stratified analyses between IGFBP3 rs2270628 C>T polymorphism and NSCLC risk by sex, age, BMI, smoking status, and alcohol consumption

Variable	IGFBP3 rs2270628 C>T (case/control)a			Adjusted ORb (95% CI); P
	CC	CT	TT	CC	CT	TT	CT/TT	TT vs (CT/CC)
Sex
Male	188/382	84/183	15/22	1.00	0.91 (0.65–1.27); 0.573	1.39 (0.67–2.88); 0.376	0.96 (0.70–1.32); 0.794	1.43 (0.70–2.94); 0.332
Female	146/288	79/135	9/19	1.00	1.11 (0.79–1.57); 0.554	0.96 (0.42–2.20); 0.920	1.09 (0.78–1.53); 0.605	0.93 (0.41–2.10); 0.854
Age (years)
<60	155/309	71/152	12/14	1.00	0.94 (0.66–1.34); 0.735	1.90 (0.81–4.47); 0.139	1.01 (0.72–1.43); 0.940	1.94 (0.83–4.51); 0.125
≥60	179/361	92/166	12/27	1.00	1.06 (0.77–1.47); 0.725	0.87 (0.42–1.79); 0.695	1.03 (0.76–1.41); 0.841	0.85 (0.41–1.74); 0.654
Smoking status
Never	201/541	103/252	13/34	1.00	1.07 (0.80–1.42); 0.656	0.98 (0.50–1.92); 0.946	1.06 (0.80–1.39); 0.704	0.96 (0.49–1.86); 0.893
Ever	133/129	60/66	11/7	1.00	0.88 (0.57–1.35); 0.561	1.53 (0.57–4.08); 0.399	0.94 (0.63–1.42); 0.783	1.59 (0.60–4.21); 0.352
Alcohol consumption
Never	283/623	139/287	22/38	1.00	1.07 (0.83–1.38); 0.594	1.18 (0.67–2.08); 0.560	1.08 (0.85–1.38); 0.515	1.16 (0.66–2.02); 0.611
Ever	51/47	24/31	2/3	1.00	0.68 (0.34–1.35); 0.268	0.78 (0.12–5.26); 0.802	0.69 (0.35–1.34); 0.269	0.90 (0.14–5.91); 0.909
BMI (kg/m2)
<24	210/353	107/171	20/22	1.00	1.08 (0.79–1.47); 0.642	1.58 (0.82–3.05); 0.171	1.13 (0.84–1.52); 0.407	1.54 (0.81–2.95); 0.190
≥24	124/317	56/147	4/19	1.00	0.92 (0.63–1.35); 0.670	0.54 (0.18–1.66); 0.285	0.88 (0.60–1.28); 0.493	0.56 (0.18–1.69); 0.303

Notes:

^aFor IGFBP3 rs2270628 C>T, the genotyping was successful in 521 (100%) NSCLC cases and 1,029 (99.90%) controls.

^bAdjusted for multiple comparisons (age, sex, BMI, smoking status, and alcohol consumption [besides stratified factors accordingly]) in a logistic regression model.

Abbreviations: NSCLC, non-small-cell lung cancer; BMI, body mass index.