Table 9.
Stratified analyses between IGFBP3 rs6953668 G>A polymorphism and NSCLC risk by sex, age, BMI, smoking status, and alcohol consumption
| Variable |
IGFBP3 rs6953668 G>A (case/control)a
|
Adjusted ORb (95% CI); P
|
||||||
|---|---|---|---|---|---|---|---|---|
| GG | GA | AA | GG | GA | AA | GA/AA | AA vs (GA/GG) | |
| Sex | ||||||||
| Male | 254/523 | 31/60 | 2/3 | 1.00 | 1.14 (0.70–1.87); 0.593 | 0.63 (0.10–3.91); 0.623 | 1.10 (0.68–1.78); 0.700 | 0.63 (0.10–3.86); 0.613 |
| Female | 212/397 | 22/44 | 0/1 | 1.00 | 0.94 (0.54–1.61); 0.811 | – | 0.92 (0.53–1.58); 0.754 | – |
| Age (years) | ||||||||
| <60 | 217/429 | 21/43 | 0/2 | 1.00 | 1.02 (0.57–1.80); 0.960 | – | 0.96 (0.54–1.69); 0.877 | – |
| ≥60 | 249/491 | 32/61 | 2/2 | 1.00 | 1.07 (0.66–1.71); 0.791 | 0.97 (0.13–7.16); 0.974 | 1.06 (0.67–1.69); 0.802 | 0.96 (0.13–7.11); 0.969 |
| Smoking status | ||||||||
| Never | 281/741 | 36/84 | 0/1 | 1.00 | 1.17 (0.76–1.79); 0.474 | – | 1.15 (0.75–1.76); 0.519 | – |
| Ever | 185/179 | 17/20 | 2/3 | 1.00 | 0.81 (0.41–1.60); 0.534 | 0.66 (0.11–4.07); 0.655 | 0.79 (0.41–1.50); 0.468 | 0.68 (0.11–4.16); 0.672 |
| Alcohol consumption | ||||||||
| Never | 399/848 | 44/96 | 1/3 | 1.00 | 1.03 (0.69–1.52); 0.897 | 0.47 (0.05–4.64); 0.514 | 1.00 (0.68–1.47); 0.998 | 0.46 (0.05–4.63); 0.513 |
| Ever | 67/72 | 9/8 | 1/1 | 1.00 | 1.16 (0.41–3.26); 0.778 | 0.82 (0.05–13.69); 0.888 | 1.12 (0.42–3.00); 0.823 | 0.80 (0.05–13.34); 0.876 |
| BMI (kg/m2) | ||||||||
| <24 | 301/486 | 34/60 | 2/0 | 1.00 | 0.96 (0.61–1.52); 0.862 | – | 1.00 (0.64–1.58); 0.991 | – |
| ≥24 | 165/434 | 19/44 | 0/4 | 1.00 | 1.18 (0.65–2.13); 0.584 | – | 1.03 (0.57–1.84); 0.930 | – |
Notes:
a
For IGFBP3 rs6953668 G>A, the genotyping was successful in 521 (100%) NSCLC cases and 1,028 (99.81%) controls.
b
Adjusted for multiple comparisons (age, sex, BMI, smoking status, and alcohol consumption [besides stratified factors accordingly]) in a logistic regression model.
Abbreviations: NSCLC, non-small-cell lung cancer; BMI, body mass index.