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. 2018 Jul 18;8(9):2991–3003. doi: 10.1534/g3.118.200447

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Copyright © 2018 de Bruyn Kops, Guthrie

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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mRNA localization phenotype in nup188-brr7. Panel A: shows electron microscopy images of wild type and nup188-brr7 1 nuclei. Black arrow indicates nuclear envelope abnormalities. Panel B: shows mRNA accumulation detected by dT50 in situ hybridization in nup188-brr7 at early times (0 min- 30’) following a shift to 16° C. DAPI staining shows the location of the cell nuclei. Panel C: shows two enlarged examples of the nuclear rim-staining pattern observed in nup188-brr7 at early times. At later times (2-6 hr), the mRNA staining becomes nucleoplasmic (Figure 1).