Figure 2.
Disease progression time course of bacterial burden (a; CFU); interleukin‐1β (b; IL‐1β), tumor necrosis factor‐α (c; TNF‐α), and cytokine‐induced neutrophil chemoattractant‐1 (d; CINC‐1) expression; neutrophil recruitment (e; N); and albumin leakage (f; ALB) during A. baumannii pneumonia at an initial inoculum of 7.00 × 106 (i), 5.76 × 107 (ii), 3.50 × 108 (iii), 4.32 × 108 (iv), and 7.65 × 109 (v) cfu/mL. Symbols indicate observed pooled data (where each observed data point represents data quantified in the terminal sample obtained from a different animal), and lines indicate model fits based on the mechanism‐based disease progression model in Figure 1. N was unobserved for the 7.65 × 109 cfu/mL inoculum.