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. Author manuscript; available in PMC: 2018 Aug 31.
Published in final edited form as: Neuroendocrinology. 2017 Aug 10;106(2):187–194. doi: 10.1159/000479875

Fig. 3.

Fig. 3.

Schematic drawing to depict environmental challenges that may modulate food intake (FI) or energy expenditure (EE) via the preoptic area (POA) and POA>hypothalamus projections that could potentially mediate metabolic adaptations of FI or EE as outlined in this review. VOLT, vascular organ of the lamina terminalis; PVH, paraventricular hypothalamic nucleus; DMH, dorsomedial hypothalamus, LHA, lateral hypothalamic area; ARC, arcuate nucleus; Glut, glutamate; GABA, γ-aminobutyric acid; PACAP, pituitary adenylate cyclase-activating peptide; BDNF, brain-derived neurotrophic factor.