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. 2018 Aug 31;13(8):e0200730. doi: 10.1371/journal.pone.0200730

Table 2. List of extracted QH features.

Modality Type Features No. of Features
H&E stained histology Tissue Component Density (TCD) Lumen, epithelium, stroma, nuclei, epithelial nuclei, and epithelial cytoplasm fractions. Epithelium/stroma, epithelium/lumen, lumen/stroma ratios. 9
Shape Area ratio, distance ratio, standard deviation of distance, variance of distance, long/short distance, perimeter ratio, smoothness, invariant moments 1-7, fractal dimension, fourier descriptors 1-10. [58] 375
Architectural: Voronoi diagram Polygon area, perimeter length, and chord length. [59, 60] 45
Architectural: Delaunay triangulation Triangle area and side length. [59, 60] 30
Architectural: Minimum spanning tree (MST) Edge length. [59, 60] 15
Architectural: nearest neighbors (NN) (a) Distance to 3, 5 and 7 NN and (b) number of NN in 10, 20, 30, 40, 50 pixel radius (PR). 120
Architectural Area, number, and density of polygons. 3
Texture Contrast energy, contrast inverse moment, contrast average, contrast variance, contrast entropy, average, variance, entropy, energy, correlation, information measure 1, information measure 2. [22] 195
Co-occuring Gland Angularity (CGA) [42] Contrast energy, contrast inverse moment, contrast average, contrast variance, contrast entropy, average, variance, entropy, energy, correlation, information measure 1, information measure 2. 195
Cell Cluster Graph (CCG) [61] Number of Nodes, Number of Edges, Average Degree, Average Eccentricity, Diameter, Radius, Average Eccentricity 90%, Diameter 90%, Radius 90% Average Path Length, Clustering Coefficient C, Clustering Coefficient D Clustering Coefficient E, Number of connected components, giant connected component ratio average connected component size, number isolated nodes, percentage isolated nodes number end nodes, percentage end nodes, number central nodes, percentage central nodes mean edge length, standard deviation edge length, skewness edge length, kurtosis edge length. 37