Table 2. Interaction effects of serum K and respectively, rs5215 and rs5219 on incident diabetes in 11,812 ARIC-JHS participants, overall and by race.

	Overall	P	Whites	P	Blacks	P
Minimally Adjusted, Model 1	OR (95% CI)		OR (95% CI)		OR (95% CI)
Serum K X rs5215
2.5 ≤ K < 4.1	0.88 (0.73, 1.05)	0.162	0.88 (0.71, 1.1)	0.259	1.05 (0.57, 1.91)	0.884
4.1 ≤ K < 4.4	1.03 (0.87, 1.21)	0.745	1.03 (0.85, 1.24)	0.781	1.26 (0.69, 2.3)	0.446
4.4 ≤ K < 4.7	1.01 (0.85, 1.19)	0.910	0.96 (0.8, 1.16)	0.691	1.15 (0.58, 2.28)	0.698
4.7 ≤ K ≤ 5.5	1 (ref)		1 (ref)		1 (ref)
Serum K X rs5219
2.5 ≤ K < 4.1	0.89 (0.74, 1.07)	0.223	0.9 (0.72, 1.12)	0.325	0.89 (0.46, 1.74)	0.734
4.1 ≤ K < 4.4	1.04 (0.88, 1.23)	0.637	1.05 (0.87, 1.27)	0.610	1.07 (0.56, 2.06)	0.830
4.4 ≤ K < 4.7	1.02 (0.86, 1.2)	0.826	0.97 (0.81, 1.16)	0.737	1.11 (0.53, 2.33)	0.782
4.7 ≤ K ≤ 5.5	1 (ref)		1 (ref)		1 (ref)
Fully Adjusted, Model 2
Serum K X rs5215
2.5 ≤ K < 4.1	0.9 (0.73, 1.09)	0.279	0.84 (0.66, 1.07)	0.169	1.09 (0.57, 2.11)	0.788
4.1 ≤ K < 4.4	1.03 (0.86, 1.23)	0.773	0.99 (0.8, 1.21)	0.900	1.42 (0.73, 2.74)	0.302
4.4 ≤ K < 4.7	1.03 (0.85, 1.23)	0.789	0.98 (0.8, 1.2)	0.834	1.25 (0.59, 2.66)	0.554
4.7 ≤ K ≤ 5.5	1 (ref)		1 (ref)		1 (ref)
Serum K X rs5219
2.5 ≤ K < 4.1	0.92 (0.75, 1.12)	0.404	0.85 (0.67, 1.09)	0.194	0.9 (0.43, 1.89)	0.777
4.1 ≤ K < 4.4	1.03 (0.86, 1.23)	0.757	1 (0.82, 1.23)	0.974	1.1 (0.53, 2.26)	0.799
4.4 ≤ K < 4.7	1.03 (0.86, 1.23)	0.776	0.98 (0.8, 1.2)	0.843	1.15 (0.51, 2.59)	0.743
4.7 ≤ K ≤ 5.5	1 (ref)		1 (ref)		1 (ref)

Model 1- adjusted for age, sex, race (overall only), SNP (rs5215 or rs5219), K, SNP X K

Model 2- adjusted for age, sex, race (overall only), BMI, systolic blood pressure, presence of hypertension, use of ABD medications, serum creatinine, serum sodium, fasting glucose, fasting insulin, parental history of diabetes mellitus, physical activity, income, SNP (rs5215 or rs5219), K, SNP X K