Table 5. Sensitivity of AFP and the Doylestown algorithm at times before HCC diagnosis.
| Time prior to HCC diagnosis | |||
|---|---|---|---|
| Marker | 1–3 months (n = 104) | 6–9 month (n = 52) | 12 months (n = 35) |
| AFP (20 ng/mL)1 | 58% | 30% | 36% |
| Doylestown algorithm (0.50)2 | 71% | 50% | 50% |
| P value3 | 0.0550 | 0.0360 | 0.2250 |
| Power4 | 0.5530 | 0.6749 | 0.5001 |
| AFP (10 ng/mL) 5 | 68% | 42% | 54% |
| Doylestown algorithm (0.25) 6 | 87% | 69% | 82% |
| P value3 | 0.0029 | 0.0051 | 0.0166 |
| power4 | 0.9170 | 0.8774 | 0.7918 |
| AFP (100 ng/mL) 7 | 28% | 12% | 13% |
| Doylestown algorithm (0.75)8 | 44% | 19% | 31% |
| P value3 | 0.0185 | 0.021 | 0.0650 |
| power4 | 0.9259 | 0.2569 | 0.5510 |
1) Sensitivity using the indicated cut-off (see below) of AFP at either 1–3 months, 6–9 months, or 12 months before HCC detection using a cut-off of 20 ng/mL.
2) Sensitivity of the Doylestown algorithm at either 1–3 months, 6–9 months, or 12 months before HCC detection using a cut-off of 0.50 output units.
3) P value between AFP and the Doylestown algorithm using a one-sided alternative hypothesis test.
4) Power level of this difference.
5) Sensitivity of AFP at either 1–3 months, 6–9 months, or 12 months before HCC detection using a cut-off of 10 ng/mL.
6) Sensitivity of the Doylestown algorithm at either 1–3 months, 6–9 months, or 12 months before HCC detection using a cut-off of 0.25 output units.
7) Sensitivity of AFP at either 1–3 months, 6–9 months, or 12 months before HCC detection using a cut-off of 100 ng/mL
8) Sensitivity of the Doylestown algorithm at either 1–3 months, 6–9 months, or 12 months before HCC detection using a cut-off of 0.75 output units.