Table 6. Cytotoxic activities of selected Trametes spp. basidiocarp and mycelium extracts and commercial cytostatics.
Species | Extract | IC50 [μg mL-1] | |||
---|---|---|---|---|---|
HeLa | LS174 | A549 | MRC5 | ||
Trametes gibbosa | basidiocarps | 193.53 ± 8.91 Ba | >200.00 A | >200.00 A | >200.00 A |
mycelium | >200.00 A | >200.00 A | >200.00 A | >200.00 A | |
Trametes hirsuta | basidiocarps | 116.13 ± 3.14 C | 158.46 ± 37.15 B | 177.66 ± 20.17 B | 175.70 ± 1.45 B |
mycelium | 21.01 ± 1.95 E | 45.75 ± 0.02 D | 57.94 ± 5.08 C | 145.17 ± 6.48 C | |
Trametes versicolor | basidiocarps | 168.54 ± 28.90 B | >200.00 A | >200.00 A | >200.00 A |
mycelium | 42.40 ± 0.74 D | 86.12 ± 12.34 C | 65.57 ± 7.75 C | 77.37 ± 0.82 D | |
cis-DDP* | 2.10 ± 0.20 F | 5.54 ± 1.03 E | 11.92 ± 2.19 D | 14.44 ± 1.90 E | |
Doxorubicin* | 0.62 ± 0.30 G | 3.78 ± 0.49 F | 0.24 ± 0.02 E | 0.46 ± 0.18 F |
a Means with different letters within a column are significantly different (P<0.01)
*Commercial cytostatic