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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Radiat Res. 2018 May 29;190(2):164–175. doi: 10.1667/RR14993.1

FIG. 7.

FIG. 7.

BH4, NO and ET-1 levels were altered in decedents. Plasma BH4, NO and ET-1 concentrations were measured longitudinally in survivors and decedents from preirradiation through necropsy. Significant reduction in the production of BH4 (panels A and B) as well as NO (panels D and E) was evident in decedents compared to survivors. The concentration of BH4 and NO at preirradiation vs. euthanasia are shown in panels C and F, respectively. Plasma ET-1 levels from individual survivors (panel G) and decedents (panel H) and average ET-1 levels at preirradiation and at euthanasia (panel I). There was no statistically significant difference in the concentration of ET-1 in decedents compared to survivors (panel I). Values shown at day 45 in survivors (panels A, D and G) and decedents (panels B, E and H) are BH4, total nitrite and ET-1 levels at euthanasia (Euth). Student’s paired t test was used for comparison of preirradiation to euthanasia. n = 8/group. *P < 0.01; **P < 0.001. BH4 = tetrahydrobiopterin; NO = nitric oxide; ET-1 = endothelin-1.