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Increased ratios of ET-1 to BH4 and ET-1 to nitric oxide. Fold changes in the ratios of individual animals in the expression of ET-1 to BH4 (panels A and B) and ET-1 to NO (panels D and E). Each symbol represents an individual animal. Average ratios of ET-1 to BH4 (panel C) and ET-1 to NO (panel F) were increased at euthanasia compared to their preirradiation levels. n = 6-8; Wilcoxon signed rank test, *P < 0.05. BH4 = tetrahydrobiopterin; NO = nitric oxide; ET-1 = endothelin-1.
