Skip to main content
. 2018 Aug 20;128(9):4086–4097. doi: 10.1172/JCI120966

Figure 4. Met amplification and Hgf overexpression in recurrent tumors.

Figure 4

(A) IGV of copy number changes determined by FACET from exome sequencing reads of recurrent ATCs. Focal amplification of chromosome 6 was seen in 5 of 11 tumor relapses. The minimal common amplicon includes Tfec, Tes, Cav2, Cav1, Met, Capza2, and St7. (B) Quantitative RT-PCR demonstrates overexpression of Met and Hgf in recurrent tumors with Met amplification. Bars represent the fold change in expression of Met and Hgf compared with primary ATCs. Quantitative RT-PCR for primary ATCs and recurrent tumors were run in triplicate.