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. 2018 Aug 20;128(9):4057–4073. doi: 10.1172/JCI96400

Figure 9. The stabilin-2 ligand hyaluronic acid modifies the immune response to human pdVWF-FVIII.

Figure 9

(A) Normal C57BL/6 mice received intravenously 2 IU human pdFVIII (complexed with pdVWF at a 1:2.4 ratio) with 100 μg hyaluronic acid (HA) weekly for 4 weeks (n = 10 for all conditions). On week 5, blood was collected and assayed for anti-VWF and anti-FVIII IgG. (B) Titer of anti-VWF IgG in mice receiving pdFVIII with or without hyaluronic acid. (C and D) Anti-FVIII IgG titer (C) and incidence (D) in mice receiving pdFVIII with or without hyaluronic acid. Throughout figure, *P < 0.05, **P < 0.001 as determined by Fisher’s exact test or Mann-Whitney U.