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. 2018 Jul 7;10(9):2151–2167. doi: 10.1093/gbe/evy144

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© The Author(s) 2018. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 6. — —Sequence alignment of Lopx homeodomain and N-terminal flanking region (a) and a C-terminal conserved motif unique to Lopx proteins (b) from a selection of lophotrochozoan species, compared with gene families/classes that Lopx genes have been mistaken for by automatic annotation pipelines (Otx/ceh-37—marked with asterisks) and in general homeodomain trees (CUT class—marked with dagger). Identities (full stops) are marked relative to the sequence of Spirobranchus lamarcki Lopx. The S. lamarcki Lopx sequence is highlighted in red. Full sequence details are included in supplementary file 1, Sheet 6, Supplementary Material online. Annelid species: S.lam, Spirobranchus lamarcki; C.tel, Capitella teleta; P.dum, Platynereis dumerilii. Brachiopod species: L.ana, Lingula anatina. Mollusc species: C.gig, Crassostrea gigas; L.gig, Lottia gigantea; P.vul, Patella vulgata; M.yes, Mizuhopecten yessoensis (syn. Patinopecten yessoensis); B.gla, Biomphalaria glabrata; O.bim, Octopus bimaculoides. Ecdysozoan species: C.ele, Caenorhabditis elegans; T.cas, Tribolium castaneum. Deuterostome species: B.flo, Branchiostoma floridae.