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. Author manuscript; available in PMC: 2018 Sep 3.
Published in final edited form as: Angew Chem Int Ed Engl. 2018 Aug 3;57(36):11629–11633. doi: 10.1002/anie.201805187

Figure 1.

Figure 1

A vacant deep hydrophobic pocket in crystal structure of WT EGFR in complex with osimertinib (top, PDB: 4ZAU); a novel pyrimidine-based carbamate series (bottom).